The DLC is a follow-up to another DLC, Through the Ashes, which focuses on the story of a different set of characters than the main campaign. The story of Sendri and Rekarth is continued, with plot points related to the game’s main campaign also being revealed along the way. The Lord of Nothing can be played as either a continuation of Through the Ashes, or as a standalone campaign with fresh characters.

Along with new story content, The Lord of Nothing also brings with it a host of new character options, including new archetypes, spells, and feats. The DLC release has been accompanied by a major update that, among other things, includes a complete rework of the Assassin class, along with new spells, animations, and mythic feats.