Deus Ex – Gray Death
Not everyone is fit to be injected with nanites. If the body rejects the injection the host can quickly fall ill, their body turning frail and gray. It was used as a biological weapon in Deus Ex, killing those who were too weak to accept the nanites. But a side effect of this was a mass illness, with throngs of people slowly dying. There was a cure but it was more than a little difficult to come by.
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