15 Video Game Scientists That Will Give Players A Hard Time 

Nolan Stross – Dead Space 2

Unlike so many others on this list, Stross is more of a pitiable figure than an evil mastermind with a paediatric M.D. Under the influence of the Red Marker, the doctor slips ever deeper into insanity, haunted by visions of his wife and daughter, which were killed by his own hand under his delusions. Isaac Clarke fought to keep him alive and bring him back, only to have Stross lose himself completely and Clarke be forced to kill him in self defence.