Clearly, they will talk about Shin Megami Tensei 4 FINAL and Etrian Odyssey 5.
Atlus are now teasing some announcements for E3on their Instagram channel- and as is the case with anything that this company does, this teasing has the fans in a tizzy. Speculations abound on exactly what Atlus may be readying for E3 this year, though it’s not necessarily hard to guess- Shin Megami Tensei 4 FINAL, the sequel to the superlative Shin Megami Tensei 4, and Etrian Odyssey 5 are both due for the Nintendo 3DS later this year. Atlus will probably take the stage at E3 to announce their localizations.
That, plus the highly anticipated Persona 5 for the PlayStation 3 and PlayStation 4 is also due out later this year worldwide, unless Atlus decide to delay it again (wouldn’t surprise me at this point).
E3 2016 is just three months away at this point, so we’ll find out soon- but I certainly hope a concrete release date for Persona 5 is finally announced.