Resident Evil Series – 10 Best Final Boss Fights

Wesker – Resident Evil 5

A long-time villain like Wesker needed a final battle of epic proportions to send him off, and Resident Evil 5 arguably over-delivered. From firing rockets, which he catches, to a crazy sequence on a cargo plane, Chris and Sheva battle a new mutated Wesker inside a volcano. Long story short, Chris punches a boulder, Wesker sinks into lava, and the two heroes both fire rockets to send him off for good. Truly a finale for the ages, and an incredible conclusion to the years-long enmity between Wesker and Chris.