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Wesker – Resident Evil 5
A long-time villain like Wesker needed a final battle of epic proportions to send him off, and Resident Evil 5 arguably over-delivered. From firing rockets, which he catches, to a crazy sequence on a cargo plane, Chris and Sheva battle a new mutated Wesker inside a volcano. Long story short, Chris punches a boulder, Wesker sinks into lava, and the two heroes both fire rockets to send him off for good. Truly a finale for the ages, and an incredible conclusion to the years-long enmity between Wesker and Chris.
