Players on PS4 can match with those on PS5, while Xbox Series X/S and Xbox One players can experience the game together.
Producer Coralie Feniollo says it's a "brand new adventure" in the same world, but fans can spot some nods and secrets to link the series.
Low and Alone enter the sand-covered Necropolis while sneaking and running for their lives from Monster Baby in this pre-alpha gameplay.
Though developer Supermassive Games considered including couch co-op, it felt that would have taken away from the game's atmosphere.
The sequel features two new characters trying to escape from Nowhere. It's coming to Xbox, PlayStation, PC, and Nintendo Switch.