A great deal of progression in Resident Evil Requiem involves puzzle solving to get through obstructions. This includes finding specific key items scattered around various locations, and using or combining them to unlock doors and paths forward.
This guide is a complete list of every item that can be considered a key to further story progress in Resident Evil Requiem, as well as the maps needed to help get your bearings.
Wrenwood
Old Key
In the Lounge at The Wrenwood Hotel, shine the flashlight at the far pillar and examine the back of the photo taped to it.
The Wrenwood Hotel Floor Plan
Check the wall to the right of the desk for this framed map of the hotel.
Wire Cutters
On the upper floor of The Wrenwood Hotel, check the disused pool table at the top of the stairs for a box containing the Wire Cutters.
Emergency Exit Key
Acquired by default through progression.
Rhodes Hill – Care Center
Cherub Key
In the side table drawer next to the upholstered armchair at the end of the hallway near the locked shutter. Required to unlock Room 201.
Lighter
Inside the now unlockable Room 201, check the shelving right by the glowing green fusebox in the rear room.
Screwdriver
In the Nurses’ Station, look for the medical cart that you can hold. Do not move it just yet, because the locker right next to it has Grace’s first Antique Coin atop it, and this is your only opportunity to acquire it by clambering up on top of the cart.
Next, look for a red toolbox atop high shelving diagonally opposite the locker, dimly lit by the glow of a control panel. Move and climb up on the same cart in order to reach it and find the screwdriver inside.
Fuse
Back in Room 201, use the Screwdriver to unscrew and open the glowing green fusebox there in order to acquire the Fuse. This Fuse will open the locked shutter back where you acquired the Cherub Key, upon insertion.
West Wing Keycard
Acquired by default through progression.
Accesses the West Wing door via the Central Hall.
West Wing Map
After heading up the stairs past the Filing Room, examine the map on the wall.
Red Jewel
Examine and unlock the Unicorn Trinket Box lying on a lamp lit table right by the door of the Chairman’s Office.
On Insanity difficulty, this location shifts to the rear room.
Pencil
Acquire the Pencil from the desk in the rear room of the Chairman’s Office. Use it to pencil-shade the indents in the open notebook lying on the coffee table in the outer Chairman’s Office, and view the combination for the Puzzle Box there.
Moon Quartz
Received after solving the Chairman’s Office Puzzle Box, and subsequently used on the Quartz Door in the Central Hall.
East Wing Keycard
Return to the lower floor, and use the previously acquired Red Jewel on the indented Parlor door in order to gain access to the room.
Examine the torn arm on the ground by the low table.
Pantry Key
Take down the cleaver-wielding enemy roaming out of the Kitchen to acquire this key.
Blood Specimen (Denatured)
In the purple test tube holder on the computer desk. Put it in the Analyzer right there on the left.
Allows crafting of Handgun Ammo and Hemolytic Injector.
East Wing Map
Continue right from the Waiting Room, down the short hallway and into the room with the stairway leading up.
Once at the top of the stairs, observe the wall above the small corner table with the lit lamp on it.
ID Wristband (Level 1)
Back outside in the hallway, proceed past the East Wing Map, and rip this wristband off of the wrist on the headless corpse, right before the fight with the Chunk miniboss.
Blood Specimen (Converged)
Use the previously acquired ID Wristband to access the previously inaccessible Lv. 1 security door in the Waiting Room.
In this Closet, collect the green test tube holder and return with it to the Analyzer in the Blood Lab.
Allows crafting of 12.7x55mm Ammo and Med Injector.
Blood Specimen (Reversible)
On the medical cart in the corner right by this table is white test tube holder. Take it to the Analyzer outside.
Allows crafting of Steroids and Stabilizer.
Wrench
In a green caddy beside the typewriter on the desk inside the Custodian’s Office.
Organ Transport Box
Down the hall from the Custodian’s Office, and through the Garage. Find it in the back of a partially open truck.
Artificial Heart
Use the previously acquired Wrench to turn the hexagonal bolt holding the Cold Storage shut, and then take the Artificial Heart off of the rack inside.
Sun Quartz
Received after solving the Lead Researcher’s Office Puzzle Box, and subsequently used on the Quartz Door in the Central Hall.
Artificial Lungs
Received after solving the Organ Transport Box puzzle.
ID Wristband (Level 2)
Back in the Examination Room, use the previously acquired Artificial Heart and Artificial Lungs on the body with the organs removed. After the corpse arises, kill it again and loot it for the wristband.
ID Wristband (Level 3)
Enter the Security Manager’s Office past this desk, and find an unusable Puzzle Box. Acquired by default through progression.
Rhodes Hill – Care Center Basement
Joint Plug #1
At the Power Distributor in the Holding Cells, near the lever that needs to be pulled.
Joint Plug #2
In the furnace room, by the forklift.
Square Socket Wrench
Take a Joint Plug to the Power Distributor to the north-east of the Boiler Room. Once through the door, get past the crate and the fence to find the wrench in a red toolbox.
Forklift Key
To the far south-west in Processing. Use the previously acquired Square Socket Wrench on the button, and the two Joint Plugs to get through the door.
Map: Care Center Basement Floor Plan
On a table with a Pouch after using the Forklift Key to open the door.
Joint Plug #3
Leaving one Joint Plug in place, insert another into the Forklift. Carefully avoid the corpse bags as you follow their progress, until you can reach the cart to push it out of the way.
Go back to the start, and swing the lever switch.
Return to the new path at the cart, once again following along with the body bags.
Drain the room by rotating the wheel, cross the now empty pool, and retrieve Joint Plug #3.
Star Quartz
Acquired by default through progression.
Severed Hand
Look back at the elevator after the cutscene.
Rhodes Hill – Care Center Courtyard
Hourglass
On the desk in the VIP Suite.
Helicopter Key
On the monitor table in the Private Lab.
Rhodes Hill – Water Treatment Plant
Crank Lever
On shelving in the Filing Room.
Raccoon City – East Raccoon City
Tactical Tracker
Atop the Supply Box in Central Camp.
Cedarbrook Apartments Key
After gaining entry to Logistics Warehouse 2F via Central Camp, ascend the upper floor and look for a box on the wall with the key inside.
Distributor
In a yellow container at the northern end of the Logistics Warehouse Roof.
Battery #1
On the wall in the top left corner of the Underground Parking Garage.
Valve Handwheel
Lying on some rubble at the bottom level of the Sewage Facility.
Battery #2
Use the previously acquired Valve Handwheel on the panel nearby. Climb back up to use the makeshift bridge and get across to another battery behind the door.
BSAA Container Keys
After using both previously acquired Batteries to get through the flooded garage, bear left. Acquired by default through progression.
Rusty Crank
Make your way up through Cedarbrook Apartments, then back down until you reach a door with the Rusty Crank in a panel next to it. Acquired by default through progression.
Broken Signal Receiver
In a yellow container at the northern end of the Cedarbrook Apartments Roof.
Distributor & Broken Signal Receiver
Combined once the Broken Signal Receiver and the Distributor are in your possession.
Gas Can
Standing on the crate in the southern end of the Gas Station.
Gas Can with Fuel
Bring the previously acquired Gas Can to the fuel tank at the northern end of the Gas Station exterior and fill it up.
Repair Kit
Within BSAA Container 02.
Distributor & Signal Receiver
Repaired once the Repair Kit and the Distributor & Broken Signal Receiver are in your possession.
Relay
In a yellow container at the northern end of Willis Tower.
Detonator
Combined once the Relay and the Distributor & Signal Receiver are in your possession.
Raccoon City – Raccoon City Center
Locker Key
After acquiring the two Scavenger Hunt Files in the S.T.A.R.S. Office, return down to the Operations Room.
Climb the wooden pallets near the chalkboard to find the key in the ceiling host of the TV.
Mechanic Jack
Lying on the ground in the northern section of the Library.
Orphanage
Hatch Key
At the southern end of the Director’s Office, turn on the desk lamp, then open the drawers of the bureau nearby to reach the key on the wall.
ARK
Override Key (Dump Control Room)
Readily visible on a large control panel on the right side of the Chemical Storage room.
Magnetic Key
Use the previously acquired Override Key in the Dump Control Room, then look directly behind you at the wall.
Noblesse Orb
Inside a red box in the Operations Room.
Animus Orb
Inside another red box in the Cleanroom.
Override Key (Bioweapon Repository 11)
On the wall on the right side of Systems Management.
Those are all of the key items needed for story progression in Resident Evil Requiem.
