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Abomination 
You have seen him featured in comics, and more notably the Incredible Hulk movie. Abomination is quite a challenge to the Hulk and often wants to take down the green monster, and has tried and came close to succeeding. Emil Blonsky purposely had himself infected with triple the amount of gamma that the Hulk originally had. However, it turned him into a monstrous amphibious reptoid as being originally more than twice the strength of the normal calm Hulk, at the cost of never being human again.
