6. Trauma Centre Series
Representing the pressure of the very surgery it attempts to simulate, Trauma Centre is a Nintendo property that pulls absolutely no punches in spite of its cartoon aesthetic. It may not look that hard, but one particular section of the original saw you have to quell a virus that duplicated itself, and boy was it a frustratingly hard experience. Recent TC games have been a bit easier, but the ones on the Wii have remained a difficult prospect. I think it's more to do with the inaccuracies of the Wiimote more than anything, but it's a tough game to crack all the same.
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