Resistance 2
The entire plot of Resistance 2 revolves around Sgt. Nathan Hale slowly being taken over by the Chimera virus while he hunts for Daedalus, a prime leader of the Chimeran forces. Though Hale eventually succeeds in killing Daedalus (albeit with Echo Squad being mostly wiped out) and taking down the enemy’s fleet, he’s eventually overcome by the virus. By the end, squad member Corporal Joseph Capelli is forced to kill Hale. On the one hand, you could argue that this was inevitable, both given the nature of the Chimera virus and humanity’s attempts to use it to fight back. However, it’s also kind of sad to see Hale reduced to this state after he fought so hard throughout the game, making one wonder about the point of it all.
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