Borderlands 2
Though more of a loot shooter than anything else, Borderlands 2 packed in a ton of different side missions to keep players occupied while learning more about the world. The best part is that each mission had some manner of hilarity to it, whether you were starting a gang war or taking part in a Top Gun-themed revenge mission or finding various forms for a robot that wants to be human but keeps attacking you in each new body.
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