The first instalment in the fantasy series' next trilogy will have around 400 people working on it by the middle of this year.
CD Projekt RED confirms its four flagship releases so far have sold over 100 million units put together.
The developer says it is "overstaffed" and won't have "other opportunities" for surplus employees across its upcoming projects.
The open world RPG megaton is continuing to rack up sales, while the series has collectively sold over 75 million units.
Most of the layoffs are from The Molasses Flood, with 21 team members in the United States and eight in Poland affected.
CD Projekt announced a "new framework" for Project Sirius last week, with layoffs following shortly after at the Boston-based studio.
CD Projekt confirmed earlier this year that The Molasses Flood's Project Sirius was being re-evaluated.
The Polish company recently confirmed that it was "formulating a new framework" for the title, codenamed Project Sirius.
The developer says the engine was "one of the reasons behind saying we want to release three big Witcher games within six years."
CD Projekt has said in a recent announcement that it is "formulating a new framework" for the title codenamed Project Sirius.
Job ads have revealed potential details on the spinoff, which will seemingly also include multiple game modes, a branching storyline, and more.
However, the company reiterates that it currently has no plans for a second season of the highly-acclaimed Netflix anime.
CD Projekt RED confirms the upcoming remake will be a fully open world game. The developer describes it as "a modern reimagining."
Formerly known as Project Canis Majoris, the remake is in the early stages of development at Fool's Theory, led by ex-Witcher developers.
After a tough couple of years, what must the Polish company do to win back the trust of the masses?
It looks like CD Projekt RED doesn't plan on repeating the mistakes it made during Cyberpunk 2077's development.
CD Projekt RED it will implement multiplayer in "most of" its future titles in order to "enrich the single player experience."
"Like the first saga was three games, so now we are thinking about more than one game," said CD Projekt's Adam Kiciński about the new saga.
The Polish studio confirms that in addition to The Witcher series' next instalment, another AAA project has also entered development.
Though it's going to be several years before the next Witcher game launches, we're already hoping for it to make some key changes.