S.T.A.L.K.E.R.: Shadow of Chernobyl
Though it doesn’t go all the way in simulating injuries and status effects, getting shot will result in continuous health loss from bleeding, which must be treated with bandages and first aid kits. It can also stop automatically, though it’s advised not to wait. Hunger can adversely affect stamina and even result in death if not taken care of, and radiation will rapidly drain health (though it doesn’t cause any long-term sickness, oddly enough).
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