Infectonator 3: Apocalypse
Most of these games involve the shooting and killing of the Zombies, but Infectonator 3 goes the other way, wanting you to release your own virus and trigger the dominoes of the end of the world. You can upgrade your virus, spice DNA and unlock a whole zoo of undead creatures to unleash your specific terror. The strategy genre and unique 16-bit style helps it stand out from any other game on this list.
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